Protein Details: P2X purinoceptor 2

Protein ID

ICDB_Pro_0249

Protein Name

P2X purinoceptor 2

Gene Name

P2RX2

Organism

Cavia porcellus (Guinea pig)

Length

474 amino acids

AlphaFoldDB

AF-O70397-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium; sodium and calcium (By similarity). Activation by extracellular ATP induces a variety of cellular responses; such as excitatory postsynaptic responses in sensory neurons; neuromuscular junctions (NMJ) formation; hearing; perception of taste and peristalsis. In the inner ear; regulates sound transduction and auditory neurotransmission; outer hair cell electromotility; inner ear gap junctions; and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).

Sequence

MAATHPKAPTAQRLRQGWSAFWDYETPKVIVVRNRPLGVVYRAVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITQSEHKVWDVEEYVKPPEGGSVFSIITRIEVTPFQTLGACPESIRVPNTTCHLDADCTAGELDMLGNGLRTGRCVPYYHGEAKTCEVSGWCPVEDGAAVSHFLGKMAPNFTILIKNSIHYPKFQFSKGNIAHRDMTYLRRCTFDQGFDPYCPIFRLGFIVEQAGENFTELAHRGGVIGVIINWDCDLDLPSSHCNPKYSFRRLDPKHVPASSGYNFRFAKYYRVNSTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKVYSHKKFDKVCAPSRPSSSWPVTLALILGQAPPPPRHCSSPWHLAHQAVGPQGAEQAKLLGLQNPTPYRLSEQIADTPDRCVGQGLPSSESPLQDSTPTDPKGLAQL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 77; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 79; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 192; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 292; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 296; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 298; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 315; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"

Disease

Location

Express in organ of Corti

DOI ID

10.1016/s0378-5955(98)00065-3

RefSeq

NP_001166180.1 [O70397-1]